|
KMID : 0370220190630020070
|
|
Yakhak Hoeji
2019 Volume.63 No. 2 p.70 ~ p.74
|
|
|
Synthesis of Phenyl m-coumarylamide Analogs and Their Anti-platelet Aggregation Activity
|
|
Kim Min-Woo
Baek In-Hwan
Kwak Jae-Hwan
|
|
|
Abstract
|
|
|
|
Phenyl m-coumarylamide analogs were designed based on phenylpropanoid analogs such as coumaric acid, ferulic acid, and caffeic amide having anti-platelet aggregation activity. They prepared through concise synthetic method. Their anti-platelet aggregation was confirmed using ADP-induced rat platelet by aggregrometer. Compound 1b and 1d having dimethylamine and methoxy group on para-position of phenylamide ring, respectively, exhibit potent inhibitory activity (92.3 and 89.3% at 80 μg/mL). The results suggest that phenyl m-coumrylamide analogs could be used to develop potent anti-platelet aggregation agents.
|
|
|
KEYWORD
|
|
|
platelet, aggregation, ADP-induced, coumarylamide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|